When is tenofovir indicated for the treatment of hepatitis B (HBV) (Hep B)?

Updated: Jun 08, 2021
  • Author: Nikolaos T Pyrsopoulos, MD, PhD, MBA, FACP, AGAF; Chief Editor: BS Anand, MD  more...
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Tenofovir may be used as the first-line therapy for treatment-naïve patients. [19] This agent is preferred as an additional therapy in patients with resistance to 3TC, telbivudine, or entecavir. Tenofovir provides more potent antiviral therapy than adefovir, and it can be used as a substitute in patients who do not have an adequate response to adefovir.

Tenofovir is a nucleotide analogue (adenosine monophosphate) reverse transcriptase and HBV polymerase inhibitor.

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