What is the efficacy of adefovir for the treatment of hepatitis B (HBV) (Hep B)?

Updated: Jun 08, 2021
  • Author: Nikolaos T Pyrsopoulos, MD, PhD, MBA, FACP, AGAF; Chief Editor: BS Anand, MD  more...
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The results of 2 multicenter trials that used adefovir for 48 weeks noted that in HBeAg-positive patients who received 10 mg of adefovir daily, there was a median 3.52-log reduction of the viral load (HBV DNA) level. [86, 87] In 48% of the patients, normalized aminotransferase levels were reported, and histologic improvement was seen in 53% of the patients who received this regimen. [86] The HBeAg seroconversion rate was 12%.

Furthermore, of the HBeAg-negative population, 64% experienced histologic improvement after receiving 10 mg of adefovir for 48 weeks, and 72% had normalized aminotransferase levels. [86, 87] The serum HBV DNA level was decreased in 51% of subjects. The outcomes were maintained if treatment was continued for 44 weeks, but the benefits were lost if treatment was discontinued at 44 weeks. [86, 87] The development rate for the resistant mutations rtN236T and rtA181V has been estimated to be around 6%. [87]

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