When is adefovir indicated for the treatment of chronic hepatitis B (HBV) (Hep B)?

Updated: Aug 01, 2018
  • Author: Nikolaos T Pyrsopoulos, MD, PhD, MBA, FACP, AGAF; Chief Editor: BS Anand, MD  more...
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Answer

Adefovir is another third-line agent (not preferred) that is indicated for the treatment of chronic hepatitis B disease with evidence of active viral replication, including patients with 3TC-resistant hepatitis B. [19] This agent is a nucleoside analogue, a potent inhibitor of the viral polymerase. The efficacy of adefovir dipivoxil has been tested in HBeAg-positive, HBeAg-negative, and 3TC-resistant patients with encouraging results.


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