What therapy regimens may be prophylactic for hepatitis B (HBV) (Hep B) infection in patients with HIV infection?

Updated: Jun 08, 2021
  • Author: Nikolaos T Pyrsopoulos, MD, PhD, MBA, FACP, AGAF; Chief Editor: BS Anand, MD  more...
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In patients infected with HIV, antiretroviral therapy regimens containing 3TC or TDF may be prophylactic for HBV infection. A recent analysis examined stocked serum samples from 354 men with HIV who had not been vaccinated against hepatitis B and whose initial serum samples showed no signs of HBV. [83]

All of the patients in the study were men who had sex with men, a population in which hepatitis B infection in the presence of HIV is particularly common. An analysis of the final stocked samples from these patients found that sometime after their first serum samples were obtained, 43 (12%) of the 354 men had become infected with HBV. [83]

The investigators found that the rate of incident HBV infections was lower during periods when antiretroviral regimens using 3TC or TDF were used (0.669 incident infections in 100 person-years) than it was during periods when no antiretroviral therapy was used or when antiretroviral therapy employed neither 3TC or TDF (6.726 and 5.263 incident infections in 100 person-years, respectively). [83]

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