Is telbivudine effective for the treatment of HBeAg-negative hepatitis B (HBV) (Hep B)?

Updated: Aug 01, 2018
  • Author: Nikolaos T Pyrsopoulos, MD, PhD, MBA, FACP, AGAF; Chief Editor: BS Anand, MD  more...
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Answer

In the HBeAg-negative patients in the phase III GLOBE Trial, the response rates at 1 year were 75% for the telbivudine group and 77% in the 3TC group, whereas 88% of the telbivudine-treated patients and 71% of the lamivudine-treated patients had undetectable HBV DNA. The HBV DNA log reduction was 5.2 (telbivudine group), compared with 4.4 (lamivudine group). [72, 73]

Regarding treatment resistance, a major issue in hepatitis B disease, the reported resistance rates at 1 year were 2.6% for patients on telbivudine and 8.2% for patients on lamivudine. [72, 73]


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