Is telbivudine effective for the treatment of HBeAg-positive hepatitis B (HBV) (Hep B)?

Updated: Aug 01, 2018
  • Author: Nikolaos T Pyrsopoulos, MD, PhD, MBA, FACP, AGAF; Chief Editor: BS Anand, MD  more...
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Answer

The results of the phase III GLOBE Trial that tested the administration of 600 mg of telbivudine versus 100 mg of 3TC over a 2-year period showed that in the HBeAg-positive population, therapeutic response (defined as HBV DNA < 10,000 copies/mL, with either ALT normalization or HBeAg loss) was 75% for the patients treated with telbivudine and 67% for the patients treated with 3TC. [72, 73]

Of the patients receiving telbivudine, 26% lost the e antigen, versus 23% of the patients receiving 3TC. [72, 73]  In addition, a 6.5-log reduction of the HBV DNA was noted for the patients receiving telbivudine versus a 5.5-log reduction for the patients receiving 3TC.


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