What is the dosage regimen of pegylated IFN-a 2a (PEG-IFN-a 2a) for treatment of hepatitis B (HBV) (Hep B)?

Updated: Aug 01, 2018
  • Author: Nikolaos T Pyrsopoulos, MD, PhD, MBA, FACP, AGAF; Chief Editor: BS Anand, MD  more...
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Answer

A 48-week regimen of PEG-IFN-a 2a may induce a 27% rate of HBeAg seroconversion and a 25% rate of loss of HBV DNA. [70] In a study by Lau et al involving a 48-week regimen, after 24 weeks of follow-up the HBeAg seroconversion rate with PEG-IFN-a 2a monotherapy was 32%, compared with 27% in those receiving combination therapy with 3TC and 19% in those receiving 3TC monotherapy. [70]


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