What are the benefits of pegylated IFN-a 2a (PEG-IFN-a 2a) in the treatment of hepatitis B (HBV) (Hep B)?

Updated: Aug 01, 2018
  • Author: Nikolaos T Pyrsopoulos, MD, PhD, MBA, FACP, AGAF; Chief Editor: BS Anand, MD  more...
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Answer

PEG-IFN-a 2a has an enhanced half-life relative to the standard INF-a. Pegylation lowers the rate of absorption following subcutaneous (SC) injection, reduces renal clearance, and decreases the immunogenicity of the interferon.


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