What are the adverse effects of interferon alfa (IFN-a) for the treatment of hepatitis B (HBV) (Hep B)?

Updated: Jun 08, 2021
  • Author: Nikolaos T Pyrsopoulos, MD, PhD, MBA, FACP, AGAF; Chief Editor: BS Anand, MD  more...
  • Print

Special attention must be given to patients with HBV-decompensated cirrhosis (eg, ascites, encephalopathy) who are taking IFN-a, owing to the fact that, although they occasionally may have a treatment response, these individuals can also deteriorate further.

The adverse effects of IFN-a treatment can sometimes be severe, even devastating. Some patients cannot complete the treatment. A flulike syndrome, myelosuppression (eg, leukopenia, thrombocytopenia), nausea, diarrhea, fatigue, irritability, depression, thyroid dysfunction, and alopecia are among the adverse effects that may occur.

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!