Which medications are approved for the treatment of chronic hepatitis B (HBV) (Hep B)?

Updated: Aug 01, 2018
  • Author: Nikolaos T Pyrsopoulos, MD, PhD, MBA, FACP, AGAF; Chief Editor: BS Anand, MD  more...
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Answer

The following are medications approved for the treatment of chronic hepatitis B in adult and/or pediatric patients (adjust all dosing in the setting of renal dysfunction)  [37] :

Preferred agents

  • Pegylated interferon (PEG-IFN)-alpha-2a (adults) or IFN-alpha-2b (children) – Adult dose 180 μg weekly; pediatric dose (age ≥1 year): 6 million IU/m 2 three times weekly
  • Entecavir – Adult dose: Daily 0.5 mg (lamivudine-/telbivudine-naive persons) or 1.0 mg (those with lamivudine/telbivudine experience or decompensated cirrhosis); pediatric dose (age ≥2 years): Weight-based to 10-30 kg; for children weighing more than 30 kg, use 0.5 mg daily
  • Tenofovir dipovoxil fumarate – Adult and pediatric (age ≥12 years) dose: 300 mg daily
  • Tenofovir alafenamide – Adult dose only: 25 mg daily; no pediatric dosing

Nonpreferred agents

  • Adefovir – Adult and pediatric dose (age ≥12 years): 10 mg daily
  • Lamivudine – Adult dose: 100 mg daily; pediatric dose (age ≥2 years): 3 mg/kg daily (maximum: 100 mg)
  • Telbivudine – Adult dose only: 600 mg daily; no pediatric dosing

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