What are the multisystem manifestations of hepatitis B virus (HBV) (Hep B) infection?

Updated: Jun 08, 2021
  • Author: Nikolaos T Pyrsopoulos, MD, PhD, MBA, FACP, AGAF; Chief Editor: BS Anand, MD  more...
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The following multisystem manifestations may occur in hepatitis B virus (HBV) infection:

  • Pleural effusion and hepatopulmonary and portopulmonary syndrome may occur in patients with cirrhosis

  • Diffuse intravascular coagulation may occur in patients with fulminant hepatitis

  • Myocarditis, pericarditis, and arrhythmia occur primarily in patients with fulminant hepatitis

  • Arthralgias and arthritic (serum sickness) subcutaneous nodules may also occur, but these are rare

  • Guillain-Barre syndrome, encephalitis, aseptic meningitis, and mononeuritis multiplex may occur in patients with acute hepatitis B

  • Pancreatitis may develop

  • Aplastic anemia is uncommon, and agranulocytosis is extremely uncommon

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