What are variables that correlate with overall survival for individuals with cirrhosis or hepatocellular carcinoma (HCC) and hepatitis B (HBV) (Hep B) infection?

Updated: Aug 01, 2018
  • Author: Nikolaos T Pyrsopoulos, MD, PhD, MBA, FACP, AGAF; Chief Editor: BS Anand, MD  more...
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Answer

Cox regression analysis has identified 6 variables that independently correlate with overall survival for individuals with cirrhosis or HCC. These include age, albumin level, platelet count, splenomegaly, bilirubin level, and positivity for hepatitis B e antigen (HBeAg) at the time of the hepatitis B diagnosis. Based on the contribution of each of these factors to the final model, a prognostic index has been constructed that allows calculation of the estimated survival probability.


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