Which hepatitis B (HBV) (Hep B) mutations increase the risk of developing hepatocellular carcinoma (HCC)?

Updated: Aug 01, 2018
  • Author: Nikolaos T Pyrsopoulos, MD, PhD, MBA, FACP, AGAF; Chief Editor: BS Anand, MD  more...
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Answer

Distinct mutations associated with different HBV genotypes have been linked to an increased risk of developing HCC. Genotype C is closely associated with HCC; this appears to be related to a higher incidence of core and precore mutations in patients older than 50 years with cirrhosis and genotype C, [19] whereas genotype B is associated with HCC development in young, noncirrhotic patients and in postsurgical relapse. [35]


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