Which hepatitis B (HBV) (Hep B) mutations increase the risk of developing hepatocellular carcinoma (HCC)?

Updated: Jun 08, 2021
  • Author: Nikolaos T Pyrsopoulos, MD, PhD, MBA, FACP, AGAF; Chief Editor: BS Anand, MD  more...
  • Print

Distinct mutations associated with different HBV genotypes have been linked to an increased risk of developing HCC. Genotype C is closely associated with HCC; this appears to be related to a higher incidence of core and precore mutations in patients older than 50 years with cirrhosis and genotype C, [19] whereas genotype B is associated with HCC development in young, noncirrhotic patients and in postsurgical relapse. [36]

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!