Does chronic hepatitis B (HBV) (Hep B) increase the risk of hepatocellular carcinoma (HCC)?

Updated: Jun 08, 2021
  • Author: Nikolaos T Pyrsopoulos, MD, PhD, MBA, FACP, AGAF; Chief Editor: BS Anand, MD  more...
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Chronic hepatitis B infection is the major contributor to the development of approximately 50% of cases of hepatocellular carcinoma (HCC) worldwide. [35] Studies indicate that the level of hepatitis B virus (HBV) DNA, which indicates viral replication, is a strong predictor for cirrhosis and HCC regardless of other viral factors. [35] Approximately 9% of patients in western Europe who have cirrhosis develop HCC due to hepatitis B infection at a mean follow-up of 73 months. The probability of HCC developing 5 years after the diagnosis of cirrhosis has been established at 6%, and the probability of decompensation is 23%.

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