What is the incidence of hepatitis B (HBV) (Hep B) in the US?

Updated: Jun 08, 2021
  • Author: Nikolaos T Pyrsopoulos, MD, PhD, MBA, FACP, AGAF; Chief Editor: BS Anand, MD  more...
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Because of the implementation of routine vaccination of infants in 1992 and of adolescents in 1995, the prevalence of HBV infection has significantly declined in individuals born in the United States.

The CDC reported 3322 new cases of acute hepatitis B in 2018; however, it is believed that a large percentage of cases go unreported. [32] Two million or more people in the US have chronic HBV infection; it is estimated that foreign-born persons from high endemic areas represent more than half of the total cases. [33] The prevalence of the disease is higher among black individuals and persons of Hispanic or Asian origin.

HBV disease not only accounts for 5-10% of cases of chronic end-stage liver disease and 10-15% of cases of hepatocellular carcinoma (HCC) in the United States, it is also the dominant cause of cirrhosis and HCC worldwide.

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