Which genes may reduce hepatitis B (HBV) (Hep B) vaccine response?

Updated: Jun 08, 2021
  • Author: Nikolaos T Pyrsopoulos, MD, PhD, MBA, FACP, AGAF; Chief Editor: BS Anand, MD  more...
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It is also known that certain patients have different responses to the hepatitis B vaccine. One study found that 14% of patients who received the vaccine were low responders. [30] A greater-than-expected number of these patients were homozygotes for the HLA-B8, -SC01, and -DR3 haplotypes. It was hypothesized that because HLA II binds antigens, different haplotypes may alter the way in which vaccine peptides activate the immune system. [30]

Another study, which looked at 914 immune candidates in over 1600 patients who were given the HBV vaccine, found numerous single-nucleotide polymorphisms (SNPs) that were associated with inadequate levels of antibody response after vaccination, [31] with most found in the HLA genes.

However, one SNP was found in the 3 prime (3’) downstream region of the FOXP1 gene. This gene is a transcriptional repressor that plays a role in the differentiation of monocytes and the function of macrophages. [31]

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