What is the role of the genes IFNAR2 and IL10R2 (CRFB4) in hepatitis B (HBV) (Hep B) infection?

Updated: Jun 08, 2021
  • Author: Nikolaos T Pyrsopoulos, MD, PhD, MBA, FACP, AGAF; Chief Editor: BS Anand, MD  more...
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The IFNAR2 gene is located at 21q22.1 and encodes the IFN-alpha, -beta, and -omega receptor 2. Although it presumably is like the previous gene, with multiple functions in the immune system, at the present time it is known only to be associated with susceptibility to hepatitis B.

A study looking at this gene found that a single nucleotide polymorphism, resulting in a phenylalanine-to-serine substitution at position 8, was associated with an increased risk for chronic hepatitis B infection. [29]

IL1OR2 gene

The same study also found that a polymorphism in the IL10R2 gene (or the CRFB4 gene), also located at 21q22.11, is associated with an increased risk of chronic hepatitis B infection. This particular polymorphism results in a lysine-to-glutamic acid substitution at position 47. [29]

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