What is the role of the IFNGR1 gene in hepatitis B (HBV) (Hep B) infection?

Updated: Jun 08, 2021
  • Author: Nikolaos T Pyrsopoulos, MD, PhD, MBA, FACP, AGAF; Chief Editor: BS Anand, MD  more...
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Several additional genes are associated with susceptibility to hepatitis B infection. The IFNGR1 gene is located at 6q23.3 and encodes the interferon gamma (IFN-γ) receptor 1, which has an important role in cell-to-cell communications and can be activated in response to infection, but it is not specific to hepatitis B. [27] Patients with significant dysfunction in this gene have a particular immune deficiency that leaves them extremely susceptible to mycobacterial infections. [27]

A more subtle change in the promoter region at location -56 in this gene has shown significant association with the natural history of hepatitis B infection. Individuals with the C allele at this location were found in a study to be more likely to clear the virus, whereas individuals with the T allele at this location were more likely to have persistent viral infection. [28]

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