What is the role of oval cells proliferation in the pathogenesis of hepatocellular carcinoma (HCC)?

Updated: Aug 01, 2018
  • Author: Nikolaos T Pyrsopoulos, MD, PhD, MBA, FACP, AGAF; Chief Editor: BS Anand, MD  more...
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Answer

Oval cells are prominent in actively regenerating nodules and in liver tissue surrounding the cancer. They appear to be the principal producers of alpha-fetoprotein (AFP). Although the cellular targets of carcinogenesis have not been identified, some evidence from experimental animal models suggests that oval cell proliferation is associated with an increased risk for the development of HCC.


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