Which medications in the drug class Antidotes are used in the treatment of Acute Liver Failure?

Updated: Jun 13, 2019
  • Author: Gagan K Sood, MD; Chief Editor: BS Anand, MD  more...
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Answer

Antidotes

Antidotes neutralize toxic agents and neutralize or counteract any form of poisoning.

Penicillin G (Pfizerpen)

Intravenous penicillin G is the drug of choice for the treatment of mushroom poisoning from Amanita phalloides. Its mode of action is unclear in this setting.

Silibinin (Silibinin Plus)

Silibinin is a water-soluble derivative of silymarin, which is the active ingredient in the herbal preparation milk thistle. This agent possesses antioxidant properties that may benefit liver disease management.

Activated charcoal (Actidose-Aqua, Liqui-Char, CharcoAid)

In patients who have recently ingested Amanita phalloides, activated charcoal may bind the toxin and prevent absorption.

N-acetylcysteine (Mucomyst, Mucosil)

N-acetylcysteine is the drug of choice in acetaminophen overdose. N-acetylcysteine provides reducing equivalents to help restore depleted intrahepatic glutathione levels.


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