Which medications in the drug class Osmotic Diuretic are used in the treatment of Acute Liver Failure?

Updated: Jun 13, 2019
  • Author: Gagan K Sood, MD; Chief Editor: BS Anand, MD  more...
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Answer

Osmotic Diuretic

Intracranial hypertension in acute liver failure is managed initially by the use of osmotic diuretics such as mannitol.

Mannitol (Osmitrol)

Osmotic diuresis with intravenous mannitol is effective in the short term for decreasing cerebral edema. Administration of intravenous mannitol (in a bolus dose of 0.5-1 g/kg or 50-100 g) is recommended to treat intracranial hypertension in acute liver failure. The dose may be repeated once or twice, as needed, provided that the serum osmolality has not exceeded 320 mOsm/L. Volume overload is a risk with mannitol use in patients with renal impairment and may necessitate the use of dialysis to remove the excess fluid.


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