How are acute liver failure (ALF)–induced seizures treated?

Updated: Jun 13, 2019
  • Author: Gagan K Sood, MD; Chief Editor: BS Anand, MD  more...
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Answer

Seizures

Seizures, which may be seen as a manifestation of the process that leads to hepatic coma and intracranial hypertension (ICH), should be controlled with phenytoin. The use of any sedative is discouraged in light of its effects on the evaluation of the mental status. Only minimal doses of benzodiazepines should be used, given their delayed clearance by the failing liver. Seizure activity may acutely elevate the ICH and may also cause cerebral hypoxia and, thus, contribute to cerebral edema.


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