What is the efficacy of liver support systems in the treatment of acute liver failure (ALF)?

Updated: Jun 13, 2019
  • Author: Gagan K Sood, MD; Chief Editor: BS Anand, MD  more...
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Two other systems based on the removal of albumin bound toxins are the Prometheus device, using the principle of fractionated plasma separation and adsorption (FPSA), and the single pass albumin dialysis (SPAD). A clinical trial is in the process of recruiting patients to to compare the MARS and SPAD systems with regard to their biologic and clinical efficacy, pulsatility index of middle cerebral artery modification, and tolerance. [50]

Currently available liver support systems are not routinely recommended outside of clinical trials. In the future, hepatocyte transplantation, which has shown dramatic results in animal models of acute liver failure, may provide long-term support, but this approach remains investigational.

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