What is the role of barbiturates in the treatment of acute liver failure (ALF)?

Updated: Jun 13, 2019
  • Author: Gagan K Sood, MD; Chief Editor: BS Anand, MD  more...
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Answer

Barbiturate agents (thiopental or pentobarbital) may also be considered when severe ICH does not respond to other measures; administration of these drugs has been shown to effectively decrease ICP. Significant systemic hypotension frequently limits their use and may necessitate additional measures to maintain adequate mean arterial pressure. Doses of barbiturates for ICH are as follows:

  • Thiopental: 5-10 mg/kg IV loading dose, followed by 3-5 mg/kg IV infusion

  • Pentobarbital: 3-5 mg/kg IV loading dose, followed by 1-3 mg/kg/h infusion


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