What is the role of hepatic enzymes measurement in the evaluation of acute liver failure (ALF)?

Updated: Jun 13, 2019
  • Author: Gagan K Sood, MD; Chief Editor: BS Anand, MD  more...
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Hepatic enzymes

The levels of the transaminases (aspartate aminotransferase [AST]/serum glutamic-oxaloacetic transaminase [SGOT], and alanine aminotransferase [ALT]/serum glutamic-pyruvic transaminase [SGPT]) are often elevated dramatically as a result of severe hepatocellular necrosis.

In instances of acetaminophen toxicity (especially alcohol-enhanced), the AST and ALT levels may be well over 10,000 U/L. The alkaline phosphatase (ALP) level may be normal or mildly elevated.

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