What is the prognosis of fulminant hepatic failure (FHF) due to acetaminophen toxicity?

Updated: Jun 13, 2019
  • Author: Gagan K Sood, MD; Chief Editor: BS Anand, MD  more...
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Answer

Acetaminophen toxicity

Fulminant hepatic failure due to acetaminophen toxicity generally has a relatively favorable outcome, and the prognostic variables permit reasonable accuracy in determining the need for OLT. Patients in deep coma (hepatic encephalopathy grades 3-4) on admission have a higher mortality than patients with milder encephalopathy. An arterial pH of lower than 7.3 and either a prothrombin time (PT) greater than 100 seconds or serum creatinine level greater than 300 mcg/mL (3.4 mg/dL) are independent predictors of poor prognosis.


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