What is the global incidence of acute liver failure?

Updated: Jun 13, 2019
  • Author: Gagan K Sood, MD; Chief Editor: BS Anand, MD  more...
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International statistics

In developed nations, acute liver failure has an estimated incidence of fewer than 10 cases per million people per year. [33]  Acetaminophen (paracetamol) overdoses are prominent causes of fulminant hepatic failure in Europe and, in particular, Great Britain. Hepatitis delta virus (HDV) superinfection is much more common in developing countries than in the United States because of the high rate of chronic hepatitis B virus (HBV) infection.

Hepatitis E virus (HEV) is associated with a high incidence of fulminant hepatic failure in women who are pregnant and is of concern in pregnant patients living in or traveling through endemic areas. [32] These regions include, but are not limited to, Mexico and Central America, India and the subcontinent, and the Middle East.

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