What are the risk factors for moxifloxacin-caused acute liver failure?

Updated: Jun 13, 2019
  • Author: Gagan K Sood, MD; Chief Editor: BS Anand, MD  more...
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Answer

Fluoroquinolones are sometimes associated with mild, transient elevations in aminotransferase levels. In particular, moxifloxacin has been identified as presenting a risk for acute liver failure. A study by Paterson et al examined the risk of acute liver injury associated with the use of moxifloxacin relative to other antibiotics. Results showed an association between moxifloxacin and an increased risk of acute liver failure among adults aged 66 years or older with no history of liver disease who were admitted to the hospital for acute liver injury within 30 days of receiving a prescription for the antibiotic. [26]


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