What is the role of drugs in the etiology of fulminant hepatic failure (FHF)?

Updated: Jun 13, 2019
  • Author: Gagan K Sood, MD; Chief Editor: BS Anand, MD  more...
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Answer

Many drugs (both prescription and illicit) are implicated in the development of fulminant hepatic failure. Drug-induced liver injury (DILI) is a leading cause of emergent liver transplantation [22] ; in Western nations, DILI is the primary cause of acute liver failure in adults. [23] The more common agents are discussed below.

Idiosyncratic drug reactions may occur with virtually any medication. Fortunately, these appear to lead to fulminant hepatic failure only rarely, although they are the most common form of drug reaction to lead to fulminant hepatic failure (with the exception of acetaminophen poisoning). [23, 24, 25]


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