What vasogenic factors are involved in the pathogenesis of acute liver failure?

Updated: Jun 13, 2019
  • Author: Gagan K Sood, MD; Chief Editor: BS Anand, MD  more...
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Answer

An increase in intracranial blood volume and cerebral blood flow is a factor in acute liver failure. The increased cerebral blood flow results because of the disruption of cerebral autoregulation. The disruption of cerebral autoregulation is thought to be mediated by elevated systemic concentrations of nitric oxide, which acts as a potent vasodilator.


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