Which medications in the drug class Prokinetics are used in the treatment of Gastroesophageal Reflux Disease?

Updated: Oct 16, 2020
  • Author: Marco G Patti, MD; Chief Editor: BS Anand, MD  more...
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Prokinetic agents, such as metoclopramide (Reglan), improve the motility of the esophagus and stomach and increase the lower esophageal sphincter (LES) pressure to help reduce reflux of gastric contents. They also accelerate gastric emptying.

Prokinetic agents are somewhat effective but only in patients with mild symptoms; most patients usually require acid-suppressing medications, such as PPIs. Long-term use of prokinetic agents may have serious, even potentially fatal, complications and should be discouraged.

Metoclopramide (Reglan)

Metoclopramide is a GI prokinetic agent that increases GI motility, increases resting esophageal sphincter tone, and relaxes the pyloric sphincter.

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