How effective are prokinetic medications and reflux inhibitors for the treatment of gastroesophageal reflux disease (GERD)?

Updated: May 23, 2019
  • Author: Marco G Patti, MD; Chief Editor: BS Anand, MD  more...
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Answer

Prokinetic agents are somewhat effective but only in patients with mild symptoms; other patients usually require additional acid-suppressing medications, such as PPIs. The usual regimen in adults is metoclopramide, 10 mg/day orally. Long-term use of prokinetic agents may have serious, even potentially fatal, complications and should be discouraged.


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