What is the efficacy of proton pump inhibitors (PPIs) for the treatment of gastroesophageal reflux disease (GERD)?

Updated: May 23, 2019
  • Author: Marco G Patti, MD; Chief Editor: BS Anand, MD  more...
  • Print
Answer

A research review by the Agency for Healthcare Research and Quality (AHRQ) concluded, on the basis of grade A evidence, that PPIs were superior to H2 receptor antagonists for the resolution of GERD symptoms at 4 weeks and healing of esophagitis at 8 weeks. [32] In addition, the AHRQ found no difference between individual PPIs (omeprazole, lansoprazole, pantoprazole, and rabeprazole) for relief of symptoms at 8 weeks. For symptom relief at 4 weeks, esomeprazole 20 mg was equivalent, but esomeprazole 40 mg superior, to omeprazole 20 mg. [32]

A systematic review and meta-analysis of two randomized trials and four prospective cohort studies on the effects of PPI in obstructive sleep apnea in patients with GERD found a lack of definitive data. [33]


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!