What are the first-line medications for the treatment of mild to moderate gastroesophageal reflux disease (GERD)?

Updated: Oct 16, 2020
  • Author: Marco G Patti, MD; Chief Editor: BS Anand, MD  more...
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Answer

H2 receptor antagonists are the first-line agents for patients with mild to moderate symptoms and grades I-II esophagitis. Options include cimetidine (Tagamet), famotidine (Pepcid), and nizatidine (Axid). The US Food and Drug Administration announced voluntary recalls of ranitidine (Zantac) from the market between December 2019 and February 2020 after raising major concerns in September 2019 about drug contamination with the impurities of the carcinogenic molecule N-nitrosodimethylamine (NDMA). [29] A total withdrawal of all ranitidine products was requested in April 2020. [30]


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