What is the role of Barrett esophagus in the development of esophageal adenocarcinoma in patients with gastroesophageal reflux disease (GERD)?

Updated: May 23, 2019
  • Author: Marco G Patti, MD; Chief Editor: BS Anand, MD  more...
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Answer

Barrett esophagus with intestinal type metaplasia has malignant potential and is a risk factor for the development of esophageal adenocarcinoma (see the images below), increasing the risk of adenocarcinoma 30-40 times. The incidence of adenocarcinoma of the esophagus is increasing steadily in Western society. Currently, adenocarcinoma accounts for more than 50% of esophageal cancers in the Western industrialized nations.

Gastroesophageal reflux disease (GERD)/Barrett eso Gastroesophageal reflux disease (GERD)/Barrett esophagus/adenocarcinoma sequence.
Endoscopy demonstrating intraluminal esophageal ca Endoscopy demonstrating intraluminal esophageal cancer.

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