What are the endoscopy-based tests used to identify H pylori in the workup of acute gastritis?

Updated: Jul 12, 2020
  • Author: Sarah El-Nakeep, MD; Chief Editor: BS Anand, MD  more...
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Answer

Endoscopy-based H pylori tests

Rapid urease test (RUT)

The RUT is performed by placing a gastric biopsy specimen, obtained at endoscopy, onto a gel- or membrane-containing urea and a pH-sensitive indicator. If H pylori is present, the bacterial urease hydrolyzes urea and changes the color of the media. The sensitivity and specificity of this test is greater than 90%.

Bacterial culture

Bacterial culture of H pylori is highly specific but not widely used because of the degree of expertise required. It is used when antibiotic susceptibilities are necessary.

Histology

Histologic detection of H pylori in the biopsy specimen is another endoscopy-based test. Appropriate staining is achieved using such stains as hematoxylin and eosin, Warthin-Starry, Giemsa, or Genta.


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