What is the role of cancer immunotherapy in the pathophysiology of acute gastritis?

Updated: Jul 12, 2020
  • Author: Sarah El-Nakeep, MD; Chief Editor: BS Anand, MD  more...
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Answer

Acute gastritis has been noted in patients receiving immune-checkpoint inhibitors for cancer immunotherapy, such as pembrolizumab. Histology shows lymphocytic infiltration, mostly of the CD8+ type along with CD3+. Treatment depends mainly on a short course of corticosteroids for lympholysis. Stopping immunotherapy is mandatory only when there is a risk of gastric perforation. The condition may be discovered accidentally during follow-up positron emission tomography (PET) computed tomography (CT) scanning, because patients could be asymptomatic despite having acute gastritis. Diagnosis occurs only after exclusion of other possible causes (eg, NSAID, CMV, etc). [4]


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