What is the role of bariatric surgery in the treatment of fatty liver disease?

Updated: Apr 12, 2018
  • Author: Emily Tommolino, MD; Chief Editor: BS Anand, MD  more...
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Answer

There is evidence to indicate that bariatric surgery with appropriate weight loss results in both biochemical improvement and histologic improvement of NASH. [77] Roux-en-Y gastric bypass with repeat biopsy within 2 years has yielded improvement in 100% of patients. One study showed that 94% of repeat liver biopsies no longer met the pathologic criteria for NAFLD or NASH; another, in which repeat liver biopsies were done only in patients with NASH (not NAFLD), demonstrated that 89% no longer had NASH. [78, 79, 80, 81]

Early studies reporting possible worsening of hepatic function after rapid weight loss have not been substantiated. Thus, bariatric surgery may be a viable alternative in appropriate candidates.


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