What is the role of drug treatment for fatty liver disease?

Updated: Apr 12, 2018
  • Author: Emily Tommolino, MD; Chief Editor: BS Anand, MD  more...
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Answer

Answer

A number of studies have been initiated to evaluate the therapeutic roles of lipid-lowering agents and insulin sensitizers in the management of fatty liver. Specifically, thiazolidinediones (eg, pioglitazone and rosiglitazone), metformin, gemfibrozil, and atorvastatin have all been found to yield laboratory and histologic improvement in small uncontrolled trials. [47, 48, 49]

Thiazolidinediones have been shown to decrease inflammation in the liver in both humans and rats, with the effects lasting only as long as the medication is being delivered. [50, 51] This class of medication results in improved insulin sensitivity and universal weight gain (which has been shown to involve an increase in whole-body fat rather than total-body water). [52]


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