What are independent predictors of nonalcoholic fatty liver disease (NAFLD)?

Updated: Apr 12, 2018
  • Author: Emily Tommolino, MD; Chief Editor: BS Anand, MD  more...
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Another promising tool is the method Kotronen et al developed for predicting NAFLD, which is based on routinely available clinical and laboratory data. [35] Analysis of 470 subjects in whom liver fat content was measured with proton magnetic resonance spectroscopy showed the following to be independent predictors of NAFLD [35] :

  • Presence of metabolic syndrome and type 2 diabetes

  • Fasting serum insulin

  • Fasting serum AST

  • AST-to-ALT ratio

Validation of the score demonstrated an area under the receiver operating characteristic curve of 0.86. [35] The optimal cut-off point of –0.640 predicted increased liver fat content with a sensitivity of 86% and a specificity of 71%.

Other noninvasive commercial tests for fibrosis (eg, FIBROSpect, FibroSURE, and FibroScan) have not yet been proved useful for NASH in Western populations.

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