What is the nonalcoholic fatty liver disease (NAFLD) fibrosis score?

Updated: Apr 12, 2018
  • Author: Emily Tommolino, MD; Chief Editor: BS Anand, MD  more...
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Answer

Answer

Because fatty liver is common in the Western world and because nonalcoholic steatohepatitis (NASH) carries a 10% risk of cirrhosis, it would be desirable to have a simple blood test that could predict which patients will have worse disease. The search for such a test has led to studies of databases, rat models, scoring systems, prospective studies, and novel uses for old markers of inflammation and scarring. [6, 30, 31, 32, 33]

The readily obtained nonalcoholic fatty liver disease (NAFLD) fibrosis score—consisting of age, hyperglycemia, body mass index (BMI), platelet count, albumin level, and ratio of aspartate aminotransferase (AST) to alanine aminotransferase (ALT)—appears easy to use for this purpose and promising for helping to avoid excessive liver biopsies. [34]


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