How prevalent is cholestasis in fatty liver disease?

Updated: Apr 12, 2018
  • Author: Emily Tommolino, MD; Chief Editor: BS Anand, MD  more...
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Answer

Answer

In rare cases, patients with alcoholic steatosis have severe cholestasis. Ballard et al described five patients with alcoholic steatosis who presented with jaundice, all of whose liver biopsy results showed severe steatosis and marked cholestasis with little hepatic fibrosis. Hepatic failure characterized by progressive encephalopathy and coagulopathy developed in and led to death in two patients. [25] In a large cooperative study of alcoholic liver disease (ALD) conducted by the Department of Veterans Affairs (VA), histologic cholestasis was observed in only 19% of patients with alcoholic steatosis.


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