When is steatosis observed in fatty liver disease?

Updated: Apr 12, 2018
  • Author: Emily Tommolino, MD; Chief Editor: BS Anand, MD  more...
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Steatosis can be observed on histology in the following conditions:

  • Alcohol excess

  • Starvation

  • Total parenteral nutrition (TPN)

  • Nonalcoholic steatohepatitis (NASH) – A diagnosis of NASH can be established only when alcohol excess (>10 g/day) can be excluded

  • Drug-induced liver disease (eg, disease caused by valproic acid, tetracycline, antiviral agents such as zidovudine, amiodarone, perhexiline maleate, methotrexate, corticosteroids, or estrogens)

  • Acute fatty liver of pregnancy [23] – This can occur during pregnancy and likely results from maternal-fetal interactions related to genetic abnormalities in the mitochondrial beta-oxidation of fatty acids

  • Metabolic liver disease and other inborn errors of metabolism

  • Reye syndrome

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