Which factors increase the risk for fatty liver disease?

Updated: Apr 12, 2018
  • Author: Emily Tommolino, MD; Chief Editor: BS Anand, MD  more...
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Other factors, such as drugs (eg, amiodarone, tamoxifen, methotrexate), alcohol, metabolic abnormalities (eg, galactosemia, glycogen storage diseases, homocystinuria, and tyrosinemia), nutritional status (eg, overnutrition, severe malnutrition, total parenteral nutrition [TPN], or starvation diet), or other health problems (eg, celiac sprue and Wilson disease) may contribute to fatty liver disease. There are reports of lean families with nonalcoholic steatohepatitis (NASH). Low and high birth weights appear to not only increase the risk for development of pediatric NAFLD but also raise the risk for more severe disease. [97] Male sex may also be a risk factor, but this remains controversial. [89]

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