What is the pathophysiology of calcified nodules in coronary thrombosis?

Updated: Dec 30, 2019
  • Author: Elena R Ladich, MD; Chief Editor: Allen Patrick Burke, MD  more...
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Answer

Answer

The calcified nodule is the least common cause of coronary thrombosis (2-7%). These lesions typically contain a calcified plate with superimposed calcified nodules that result in discontinuity of the fibrous cap. The luminal thrombus is in direct contact with calcium nodules in areas devoid of endothelial cells (see the image below).

Vulnerable plaque pathology. Calcified nodule. A: Vulnerable plaque pathology. Calcified nodule. A: There is an eccentric plaque that does not result in critical stenosis; it is largely composed of calcium. B: A higher magnification of disrupted calcium nodules and fibrin resulting in extrusion into the lumen (Burke et al. Herz. 2001;26:239-44, with permission).

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