Which medications in the drug class Nitrates are used in the treatment of Esophageal Spasm?

Updated: Aug 07, 2019
  • Author: Ahmad Malas, MD; Chief Editor: BS Anand, MD  more...
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Like calcium channel blockers, nitrates may decrease the pain associated with esophageal spasm. The mechanism of action is unknown, but it may be related to decreasing vasospasm in the brainstem, similar to calcium channel blockers, or it may be due to a direct effect on the myocytes.

Isosorbide dinitrate (Dilatate SR, Isordil, Isoditrate ER)

The approved indication is for angina pectoris. Isosorbide dinitrate relaxes vascular smooth muscle by stimulating the intracellular cyclic GMP. By decreasing left ventricular pressure and dilating the arteries, it reduces cardiac oxygen demand.

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