Which medications in the drug class Toxins (botulinum toxin) are used in the treatment of Esophageal Spasm?

Updated: Aug 07, 2019
  • Author: Ahmad Malas, MD; Chief Editor: BS Anand, MD  more...
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Answer

Toxins (botulinum toxin)

This class binds receptors in nerve endings, decreasing the release of acetylcholine. Injecting botulinum toxin endoscopically above the lower esophageal sphincter (LES) improves the symptoms of patients with esophageal spasms. However, the effect is temporary and the response decreases with repeated injections.

Botulinum toxin (BOTOX®)

Botulinum toxin treats excessive abnormal contractions associated with blepharospasm. It binds to receptor sites on motor nerve terminals and inhibits the release of acetylcholine, which, in turn, inhibits the transmission of impulses in neuromuscular tissue.


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