What is the pathogenesis of esophageal spasm?

Updated: Aug 07, 2019
  • Author: Ahmad Malas, MD; Chief Editor: BS Anand, MD  more...
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Answer

The etiology of esophageal spasm is unknown. Increased release of acetylcholine appears to be a factor (sensitive to cholinergic stimulation), but the triggering event is not known. Other theories include gastric reflux or a primary nerve or motor disorder. Body mass index (BMI) and total cholesterol may be highly predictive factors for esophageal body contractility, whereas BMI and glucose may be predictive factors for lower esophageal sphincter contractile function. [2]


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