Which medications in the drug class Phosphodiesterase-5 Enzyme Inhibitors are used in the treatment of Esophageal Spasm?

Updated: Aug 07, 2019
  • Author: Ahmad Malas, MD; Chief Editor: BS Anand, MD  more...
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Phosphodiesterase-5 Enzyme Inhibitors

These agents can relax smooth muscle.

Sildenafil (Revation, Viagra)

Sildenafil acts by inhibiting cGMP-specific phosphodiesterase type 5, an enzyme that promotes the degradation of cGMP, thereby enhancing the effects of nitric oxide-activated increases in cGMP, resulting in smooth muscle relaxation.

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