Which medications in the drug class Tricyclic antidepressants are used in the treatment of Esophageal Motility Disorders?

Updated: Dec 29, 2017
  • Author: Eric A Gaumnitz, MD; Chief Editor: Praveen K Roy, MD, AGAF  more...
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Answer

Tricyclic antidepressants

Used in chronic pain management for noncardiac chest pain unresponsive to other treatment modalities.

Amitriptyline (Elavil)

Has analgesic effects for some forms of chronic and neuropathic pain.

Nortriptyline (Pamelor)

Has demonstrated effectiveness in the treatment of chronic pain. By inhibiting the reuptake of serotonin and/or norepinephrine by the presynaptic neuronal membrane, this drug increases the synaptic concentration of these neurotransmitters in the CNS. Pharmacodynamic effects (eg, desensitization of adenyl cyclase, down-regulation of beta-adrenergic and serotonin receptors) also appear to play a role in its mechanism of action.


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